AB0980 HOW DO SPONDYLOARTHRITIS START? IDENTIFICATION OF THE FIRST SYMPTOMS ACCORDING TO THE DIAGNOSIS AND HLA-B27. DATA FROM REGISPONSER AND RESPONDIA REGISTRIES

Background The definition for early spondyloarthritis (SpA) implies the correct identification of initial symptom SpA. There is currently no consensus on whether only musculoskeletal manifestations (MM) or also extra-MM (EMM) should be considered as onset Objectives a) To describe (either MM EMM) in different SpA subtypes; b) to stratified by clinical diagnosis and presence HLA-B27; c) analyze factors associated with forms initiation. Methods Observational, cross-sectional multicenter study, including patients a (Ankylosing Spondylitis (AS), AS Psoriasis (AS-Pso), Inflammatory Bowel Disease (AS-IBD), Psoriatic Arthritis (PsA), Reactive (ReA), Juvenile Spa (Juv-SpA), IBD (A-IBD) undifferentiated (u-SpA)) from REGISPONSER RESPONDIA registries. Investigators responses question “Indicate first sign attributable disease” have been recorded. date appearance each EMM feature was collected, allowing determine symptom(s) patient. Differences across between HLA-B27 carriers were compared using chi-square test. Finally, most prevalent evaluated. Results A total 4411 included. (54.9%), PsA (18.7%) uSpA (11.1%) diagnosis. In overall population, low back pain (60.3%) followed buttock (35.3%) lower limbs arthritis (39.9%). percentage who started disease according represented Figure 1. patients, absence lead an increment probability initiating cervical (25.6% vs. 15.5%), enthesitis (18.8% 12.4%) coxitis (15.7% 8.4%) comparison positives. PsA, initiation upper limb (61% 38.4%) psoriasis (62.1% 37%) more negatives, while (22.1% 13.6% 28.8%) AS-Pso, frequently peripheral features symptom. whole cutaneous psoriasis, negative involvement (arthritis, dactylitis). On other hand, female gender, axial symptoms. Conclusion this symptoms (i.e., pain, arthritis), differences depending antigen. seems cervicalgia symptom, it Funding: ancillary analysis has funded research grant “Ayudas en Investigación SER-GRESSER” Spanish Society Rheumatology (SER). Description REFERENCES: NIL. Acknowledgements: Disclosure Interests None Declared.